AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Preparing to act follows Bayesian inference rulesby Luca Tarasi on 13 Giugno 2025
Bayesian brain theories suggest that the human brain sets up predictive models to anticipate sensory evidence. Here, we propose that these models inform the entire functional hierarchy, scaling all the way down to the motor system. To test this hypothesis, 62 participants completed a probabilistic discrimination task while receiving bilateral single-pulse transcranial magnetic simulation (TMS) over the two M1s. Motor-evoked potentials (MEPs) were recorded to assess motor excitability for...
- Closing the diagnostic gap: A narrative review of recent advances in functional MRI diagnostics in spinal cord injuryby Christian J Entenmann on 11 Giugno 2025
INTRODUCTION: Conventional MRI (T1 and T2-weighted sequences) is the standard for diagnosing spinal cord injuries but often lacks specificity, showing limited correlation with microstructural changes and function. This creates a diagnostic gap, especially in patients with mild or ambiguous symptoms, delaying early intervention.
- Motor sequence learning elicits mu peak-specific corticospinal plasticityby Tharan Suresh on 11 Giugno 2025
Motor cortical (M1) transcranial magnetic stimulation (TMS) interventions increase corticospinal output and improve motor learning when delivered during sensorimotor mu rhythm trough but not peak phases, suggesting that the mechanisms supporting motor learning may be most active during mu trough phases. Based on these findings, we predicted that motor sequence learning-related corticospinal plasticity would be most evident when measured during mu trough phases. Healthy adults were assigned to...
- The effects of non-invasive brain stimulation on cognitive impairment in depression: A systematic review and meta-analysisby Xin Xia on 10 Giugno 2025
BACKGROUND: Cognition is commonly compromised in depression, and non-invasive brain stimulation (NIBS) has been well-established in the treatment of depression, but its efficacy for treating cognitive deficit has not been fully elucidated. Based on the available evidence on NIBS, we conducted a meta-analysis to systematically assess the efficacy of NIBS in improving cognitive deficits in depressed patients.
- Conducting interslice stimulation for concurrent TMS-fMRIby J B Jackson on 8 Giugno 2025
CONCLUSION: A stimulation frequency faster than 10Hz would require a shorter gap or shorter slice acquisition times. Further, stimulator intensity, slice orientation, and the number of TMS pulses affected data quality and are important considerations for researchers when setting up their own protocol.
- Network-based Near-Scalp Personalized Brain Stimulation Targetsby Ru Kong on 6 Giugno 2025
CONCLUSION: The tree-based MS-HBM algorithm provides a robust, generalizable framework to estimate near-scalp personalized targets across different populations.
- Serum Interleukin-8 Levels and Their Association with Anxiety and Functional Disability in Military Personnel with Chronic Low Back Painby Rim Dhahri on 13 Giugno 2025
Background/Objectives: Chronic low back pain (LBP) remains a leading cause of disability and healthcare utilization globally, with complex, multifactorial pathophysiology. Despite advances in imaging, diagnosis often remains challenging due to poor correlation between structural findings and clinical symptoms. Recent evidence suggests inflammatory mechanisms may underlie persistent pain. This study investigated whether systemic inflammatory cytokines are altered in military personnel with...
- Safety and efficacy of pulsed radiofrequency versus pulse dose mode radiofrequency targeting the pudendal nerve in patients with pudendal neuralgia: a prospective randomized controlled clinical trialby Saeid Elsawy on 12 Giugno 2025
CONCLUSIONS: Both pulsed radiofrequency and pulse dose radiofrequency were equally effective and safe as a treatment method for managing pudendal neuralgia cases. Considering both modalities in cases with proven pudendal neuralgia is valuable.
- Patient phenotyping for molecular profiling of neck and low back pain - Study protocolby Michele Curatolo on 12 Giugno 2025
CONCLUSION: We anticipate that comprehensive phenotyping will greatly facilitate the identification of phenotype-specific transcriptional signatures associated with chronic neck and low back pain, revealing new neurobiological and/or neuro-immunological mechanisms of painful diseases.
- Spinal Cord Stimulation Alleviates Sensitization of Neuropathic Pain by Upregulating G Protein-Coupled Receptors to Inhibit Overexpression of Cav2.2 and Its Downstream Excitatory Neurotransmittersby Si-Liang Liu on 11 Giugno 2025
CONCLUSION: SCS alleviates hyperalgesia in NP through upregulation of ORL-1 to inhibit the overexpression of Cav2.2 and its downstream neurotransmitters. This may be one of the mechanisms through which SCS induces analgesia. The elucidation of the ion channel mechanism of SCS will improve the clinical application procedures of SCS.
- Cognitive and Personality Profiles of Patients With Chronic Trigeminal Neuralgiaby Anton Pashkov on 11 Giugno 2025
CONCLUSIONS: These findings may provide valuable insights for the development of personalised treatment plans for patients with trigeminal neuralgia, specifically targeting their unique personality traits and cognitive impairments.
- Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itchby Andrew J Crowther on 11 Giugno 2025
Our understanding of neural circuits that respond to skin dysfunction, triggering itch, and pathophysiological scratching remains incomplete. Here, we describe a profound chronic itch phenotype in transgenic mice expressing the tetracycline transactivator (tTA) gene within the Phox2a lineage. Phox2a; tTA mice exhibit intense, localized scratching and regional skin lesions, controllable by the tTA inhibitor, doxycycline. As gabapentin and the kappa opioid receptor agonist, nalfurafine, but not...
- Psychological Challenges Faced by Mothers of Children with Congenital Heart Disease: A Mixed-Methods Study at a Tertiary Care Hospitalby Thillainayaki Chandran on 13 Giugno 2025
CONCLUSION: The findings underscore the severe emotional burden on mothers of children with CHD, with significant levels of depression and stress. While anxiety levels were lower, other emotional factors like grief and fear played a major role. Support mechanisms such as medical care and online communities were helpful but not sufficient. Targeted interventions to reduce emotional distress and improve mental health are essential for these mothers and their families.
- Assessment of Academic Stress and Anxiety among School-Going Children in Salem District: A Cross-Sectional Studyby Nikitha Sruthi Anand on 13 Giugno 2025
CONCLUSION: Academic stress and anxiety are pervasive issues among children, necessitating targeted interventions to address workload management, mental health support, and coping strategies.
- Effects of cognitive behavioral therapy combined with physical therapy on improving outcomes in chronic low back painby Thị Hang Tran on 13 Giugno 2025
[Purpose] This study aimed to investigate the effect of cognitive behavioral therapy (CBT) combined with physical therapy on improving outcomes in chronic low back pain (CLBP). [Participants and Methods] Participants were divided into two groups: Group A (31 participants) received CBT combined with physical therapy, and Group B (32 participants) received only physical therapy. Outcome measures at baseline and post-treatment were assessed using the Numeric Pain Rating Scale (NPRS), Oswestry...
- Innovative Mind-Body Therapy for Enhancing Psycho-Physiological Stability in Patients Undergoing Upper Gastrointestinal Endoscopy: A Randomized Controlled Studyby Sundari Mani on 13 Giugno 2025
CONCLUSION: Mind-body therapy, incorporating video-assisted education, breathing exercises, and the Mendelsohn maneuver, is an effective non-pharmacological intervention for reducing anxiety and enhancing physiological stability in patients undergoing UGIE. These findings support the integration of mind-body interventions into routine endoscopic care to improve patient outcomes. Future research should explore the long-term benefits and broader applicability of such interventions in endoscopic...
- Mental Health Status of Lactating Women Residing in Urban Slums and Rural Areas of South India: A Community-Based Cross-Sectional Studyby Chimata Naveen on 13 Giugno 2025
CONCLUSIONS: Almost one in every fourth of lactating women residing in urban slums and rural areas will suffer from mental health issues. LSCS type of delivery and class IV and V SES have a negative impact on the mental health status of lactating women from rural areas. Nuclear family, breastfeeding less than eight times per day, class IV and V SES, and unintentional pregnancy have negative impacts in urban slums.
- Anxiety and Depression in Patients With Vestibular Disordersby Bao Y Sciscent on 13 Giugno 2025
CONCLUSION: Patients with vestibular disorders have higher rates of depression and anxiety compared to the general population.
- Association between Adverse Childhood Experiences and Internalizing Symptoms in Adults at a Wellness Centre in Indiaby Riri G Trivedi on 13 Giugno 2025
CONCLUSIONS: The research extends the findings from global research on ACE and mental health (depression, anxiety) in India, highlighting the strong association. Future work should expand the samples across the geography to enhance the insights.
- Mental Health Status of Lactating Women Residing in Urban Slums and Rural Areas of South India: A Community-Based Cross-Sectional Studyby Chimata Naveen on 13 Giugno 2025
CONCLUSIONS: Almost one in every fourth of lactating women residing in urban slums and rural areas will suffer from mental health issues. LSCS type of delivery and class IV and V SES have a negative impact on the mental health status of lactating women from rural areas. Nuclear family, breastfeeding less than eight times per day, class IV and V SES, and unintentional pregnancy have negative impacts in urban slums.
- Abnormalities of lipid metabolism in the progression and treatment of depressionby Xinchi Luan on 13 Giugno 2025
Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On...
- Evaluating the efficacy of three classical EEG paradigms in the discrimination of bipolar depressionby Chen Yang on 13 Giugno 2025
CONCLUSIONS: This study indicates that the eyes closed experimental paradigm more effectively demonstrates the electrophysiological disparities between patients with BD and HCs, in comparison to the eyes open paradigm and the action observation-based free viewing paradigms, as determined through the analysis of various outcome metrics.
- The impact of living alone on older adults' mental health and the mediating role of healthy dietby Jichao Zheng on 13 Giugno 2025
CONCLUSION: Older people living alone are a vulnerable group with poor mental health and require a variety of interventions to improve their mental health. Healthy eating is one possible avenue of intervention; the Government should take diversified initiatives to enhance the healthy diet of older persons living alone.
- Social activity as a mediator between childhood adversity and depressive symptoms in middle-aged and older Chinese adultsby Ping Wu on 13 Giugno 2025
CONCLUSIONS: Social activity mediates the relationship between ACEs and DS, highlighting the importance of social engagement to reduce depression risk in this population.
- The Impact of Dietary Habits and Nutrition Knowledge on Harmful Alcohol Use and Nicotine Dependence Among Medical Students: A Single-Center, Cross-Sectional Studyby Aureliusz Andrzej Kosendiak on 13 Giugno 2025
Background: Harmful alcohol use and nicotine dependence are major public health concerns. One group particularly at risk may be medical students, who might resort to substance use as a coping mechanism for stress. Various factors may influence these behaviors, either positively or negatively-among them, dietary knowledge and eating habits. Methods: In this study, we used the KOMPAN questionnaire to assess dietary habits and nutrition knowledge, the AUDIT questionnaire to evaluate problematic...
- Cortisol and β-Endorphin Responses During a Two-Month Exercise Training Program in Patients with an Opioid Use Disorder and on a Substitution Treatmentby Alexandros E Psarianos on 13 Giugno 2025
Physical exercise may affect drug use by balancing neurohormonal system mechanisms. Cortisol and β-endorphin, associated with stress, mood, and pleasure feelings, can be affected by exercise and act as regulators of withdrawal symptoms associated with drug use during short-term abstinence. The present study investigated the effect of a supervised, two-month moderate-intensity aerobic exercise program on salivary cortisol and β-endorphin levels in patients with an opioid use disorder (OUD) and on...
- Opioid-Induced Regulation of Cortical Circular-Grin2b_011731 Is Associated with Regulation of circGrin2b Sponge Target miR-26b-3pby Aria Gillespie on 13 Giugno 2025
Opioid use induces neurobiological adaptations throughout mesolimbic brain regions, such as the orbitofrontal cortex (OFC), which mediates decision-making and emotional-cognitive regulation. Previously, we showed that a circular RNA (circRNA) species, rno_circGrin2b_011731 (circGrin2b), is upregulated in the OFC of rats following chronic self-administration (SA) of the opioid heroin. circGrin2b is derived from Grin2b, which encodes the regulatory subunit of the glutamate ionotropic NMDA...
- Exploring tryptamine derivatives as potential agents for diabetes and cancer treatment: in-vitro kinetics, molecular docking, and cell toxicity based investigationsby Majid Khan on 13 Giugno 2025
Abnormal glucose levels in diabetes mellitus cause chronic complications like neuropathy, nephropathy, retinopathy, cataract, and cardiovascular issues. Aldose reductase (AR), an enzyme in the polyol pathway, is crucial for developing treatments for diabetic complications. To this end, a series of twenty inhibitors based on tryptamine scaffolds were synthesized and assessed for their efficacy in inhibiting AR activity. The compounds showed strong to moderate inhibition of AR with IC(50) values...
- GLP-1 Analogues in the Neurobiology of Addiction: Translational Insights and Therapeutic Perspectivesby Juan David Marquez-Meneses on 13 Giugno 2025
Glucagon-like peptide-1 receptor agonists, originally developed for the treatment of metabolic disorders, have recently emerged as promising candidates for the management of substance use disorders. This review synthesizes preclinical, clinical, and translational evidence on the effects of glucagon-like peptide-1 receptor agonists across addiction models involving alcohol, nicotine, psychostimulants, and opioids. In animal studies, glucagon-like peptide-1 receptor agonists consistently reduce...
- Substance Use Treatment Services in New York (2021-2023): A State Profile Analysis Based on National Survey of Substance Abuse and Mental Health Services (N-SUMHSS) Databy Abimbola E Arisoyin on 13 Giugno 2025
CONCLUSION: MAT utilization has improved, but challenges persist in addressing the growing demand for residential and detox services. Expanding outpatient and inpatient services, along with greater access to MAT, is crucial to improving treatment in New York.
- Protein Intake and Diet Quality Mediate the Relationship Between Sleep and Handgrip Strength in Adults in the HANDLS Studyby Marie Fanelli Kuczmarski on 13 Giugno 2025
Objective: The aim of this study is to determine if protein intake, diet quality, or engagement in physical activity mediate the relationship between sleep quality or duration and handgrip strength. Methods: The sample consisted of 2171 middle-aged persons examined in the 2013-2017 Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) prospective cohort study. Those with sleep apnea (n = 222) and missing data were excluded, resulting in an analytical sample of 1308. Handgrip...
- Selective Angiography of Stimulant-Exposed Cardiac Donors Following Circulatory Death Does Not Impact Post-Transplant Outcomesby Clayton J Rust on 13 Giugno 2025
Background/Objectives: Donation after circulatory death (DCD) has emerged to expand the heart-donor pool, but many DCD donors have risk factors such as cocaine or methamphetamine use. Stimulant use can cause coronary vasospasm and premature coronary artery disease, leading to routine donor coronary angiography (left heart catheterization, LHC) for coronary screening. However, performing LHC in DCD donors is challenging. We examined whether omitting LHC in stimulant-exposed DCD donors affects...
- GLP-1 Analogues in the Neurobiology of Addiction: Translational Insights and Therapeutic Perspectivesby Juan David Marquez-Meneses on 13 Giugno 2025
Glucagon-like peptide-1 receptor agonists, originally developed for the treatment of metabolic disorders, have recently emerged as promising candidates for the management of substance use disorders. This review synthesizes preclinical, clinical, and translational evidence on the effects of glucagon-like peptide-1 receptor agonists across addiction models involving alcohol, nicotine, psychostimulants, and opioids. In animal studies, glucagon-like peptide-1 receptor agonists consistently reduce...
- Methamphetamine and Cocaine Overdose Deaths in the United States, 1999-2023by David T Zhu on 13 Giugno 2025
CONCLUSIONS: Rising stimulant mortality, particularly in racial and ethnic minoritized populations, underscores the need for expanding access to harm reduction resources, greater funding for stimulant use disorder research, and targeted public health interventions.
- In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behaviorby Maria F Ramirez on 12 Giugno 2025
Many substances/drugs are administered intranasally (IN). These include opioid overdose reversal drugs, anti-epileptic medications, migraine medications, hormone treatments, and medicines to treat/prevent allergies, colds, and flues including nasally-administered vaccines, corticosteroids, antihistamines, and decongestants. Additionally, IN administration is the preferred route of entry by users of illicit drugs. Despite the widespread use of the IN route of administration, there is no...
- Mini-review: Harm reduction strategies among people who intentionally use fentanylby Jacob Paredes on 12 Giugno 2025
CONCLUSION: Future research is needed to understand intentional fentanyl use, perceived harm reduction strategies and the efficacy of these strategies with the advent of stronger opioids. Future research about PWIUF should consider novel study designs such as the ecological momentary assessment for more granular observation of the use of harm reduction strategies.
- Validation of the Chinese version of the Yale-Brown Obsessive Compulsive Scale for Pathological Gambling for individuals with gambling disorder in Mainland Chinaby Dongli Fan on 13 Giugno 2025
INTRODUCTION: The escalating severity of gambling issues in China highlights the need for culturally adapted assessment tools. The Yale-Brown Obsessive Compulsive Scale for Pathological Gambling (PG-YBOCS) is recognized for its ability to assess both the severity and compulsive features of gambling disorder.
- For debate: Towards standardised data collection practices for gambling helplinesby Virve Marionneau on 12 Giugno 2025
No abstract
- Too Aroused to Sleep: The Role of Tilt in Playing Online Poker and First-Person Shooter Gamesby Béatrice Sasseville on 12 Giugno 2025
No abstract
- Effects of Audiovisual Cues on Game Immersion during Simulated Slot Machine Gamblingby Fiza Arshad on 12 Giugno 2025
Modern slot machines can create immersive experiences for gamblers. Design features, including audiovisual cues, may influence these experiences, potentially interacting with personal risk factors for disordered gambling. According to the incentive salience hypothesis of addiction, reward-paired audiovisual cues strongly motivate behavior. This study manipulated audiovisual cues during simulated slot machine gambling to test the effects of varying intensities on self-reported immersion....
- Gambling and adolescents: a public health crisis demanding immediate actionby Luana Stangherlin Dos Santos on 12 Giugno 2025
No abstract
- Provincial and territorial results and recommendations from the Canadian Alcohol Policy Evaluation project: Room for improvementby Isabella Priore on 12 Giugno 2025
CONCLUSIONS: P/T governments have yet to adopt many of the evidence-based alcohol policies available. Improved policy adoption across P/Ts is achievable and could help address the health, social, and economic impacts of alcohol use.
- The Joint Association of Diet Quality and Sleep Regularity with Incident Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosisby Kaitlin S Potts on 13 Giugno 2025
CONCLUSIONS: Having irregular sleep and low diet quality confers the highest CVD risk compared to having neither or only one of these behaviors. These results underscore the importance of interventions targeting these unhealthy lifestyle behaviors, especially when they co-occur.
- Analysis of Blame, Guilt, and Shame Related to Body and Body Weight and Their Relationship with the Context of Psychological Functioning Among the Pediatric Population with Overweight and Obesity: A Systematic Reviewby Kamila Czepczor-Bernat on 13 Giugno 2025
Background/Objectives: There is scientific evidence showing that body- and/or body weight-related blaming, guilting, and shaming continue to be both promoted and tolerated in many societal contexts, including schools and healthcare settings. A deeply ingrained belief still prevails among many individuals that inducing these negative emotions can serve as a motivator for children and adolescents to engage in obesity treatment. Therefore, the aim of this systematic review is to examine these...
- Feeding Difficulties in Children with Hepatic Glycogen Storage Diseases Identified by a Brazilian Portuguese Validated Screening Toolby Bárbara Cristina Pezzi Sartor on 13 Giugno 2025
Background/Objectives: Hepatic glycogen storage diseases (GSDs) are inherited metabolic disorders that affect glycogen synthesis or breakdown, primarily involving the liver and muscles. Treatment typically consists of strict dietary management, including the consumption of uncooked cornstarch. However, there is limited research on feeding challenges and the associated stress experienced by parents of children with GSDs. This study aims to assess feeding difficulties in children with GSDs and the...
- Influence of Lycopene Intake on Mental Health: A Systematic Review of Randomized Controlled Trials (RCTs)by Dominika Głąbska on 13 Giugno 2025
Background/Objectives: The potential influence of lycopene on mental health was indicated in some studies, but it was not summarized within any systematic review so far. The aim of the presented study was to analyze the influence of lycopene on mental health within a systematic review of Randomized Controlled Trials (RCTs). Methods: The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and it was based on PubMed, Web of...
- The Conclusive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED): Development and Psychometric Propertiesby Moria Golan on 13 Giugno 2025
Background: Accurately assessing eating disorder (ED) severity and treatment progress is essential for effective intervention. The Comprehensive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED) was developed to address limitations in existing assessments by incorporating behavioral, cognitive, and physiological markers. Objectives: This study aimed to examine the psychometric properties and sensitivity to symptom changes of the CONTASI-ED in a...
- Does Identifying with Another Face Alter Body Image Disturbance in Women with an Eating Disorder? An Enfacement Illusion Studyby Jade Portingale on 13 Giugno 2025
Background/Objectives: Individuals with eating disorders (EDs) experience stronger body illusions than control participants, suggesting that abnormalities in multisensory integration may underlie distorted body perception in these conditions. These illusions can also temporarily reduce body image disturbance. Given the centrality of the face to identity and social functioning-and emerging evidence of face image disturbance in EDs-this study examined, for the first time, whether individuals with...
- When Standard Is Not Enough: A Narrative Review of Supratherapeutic SSRI Doses in Resistant Obsessive Compulsive Disorderby Giacomo Gualtieri on 13 Giugno 2025
Background/Objectives: OCD is a chronic psychiatric disorder, often requiring long-term pharmacological treatment. Although selective serotonin reuptake inhibitors (SSRIs) are considered first-line agents, 40 to 60% of patients show only partial or no response when treated at standard dosages. In such cases, supratherapeutic doses of SSRIs have been proposed as an alternative strategy. However, the evidence supporting this approach remains limited and fragmented. This review aims to evaluate the...
- Atopic Dermatitis and Obsessive-Compulsive Disorder: A Systematic Reviewby Sheila Sharifi on 12 Giugno 2025
Atopic dermatitis (AD) is a prominent inflammatory skin disorder that significantly affects daily functioning and mental health in patients. Among its psychological repercussions, besides anxiety and depression, obsessive-compulsive disorder (OCD) has emerged with multiple studies indicating an increased risk of OCD in AD patients. This systematic review aims to synthesize and evaluate the current literature on the association between AD and OCD, with particular attention to mechanisms linking...
- Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?by Alanna Kit on 11 Giugno 2025
There is growing interest in exploring the therapeutic potential and mechanisms of action of psilocybin on stress-related neuropsychiatric disorders, including depression, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), addiction, and disordered eating. Despite promising progressions in preclinical and clinical research, the neurobiological and physiological mechanisms underlying the therapeutic effects of psilocybin remain complex,...
- Magnetic Resonance-Guided Focused Ultrasound Neurosurgery for Treatment-Refractory Obsessive-Compulsive Disorder: A Health Technology Assessmentby Ontario Health (Quality) on 11 Giugno 2025
CONCLUSIONS: MRgFUS neurosurgery may be an effective and generally safe treatment option for severe, treatment-refractory OCD, but the evidence is very uncertain. The cost-effectiveness of MRgFUS neurosurgery could not be determined given the lack of comparative clinical evidence. Publicly funding MRgFUS neurosurgery for people with treatment-refractory OCD in Ontario would result in an additional cost of $1.9 million over 5 years. Patients and care partners emphasized the negative impact of OCD...
- Osteochondritis dissecans in children: location-dependent differences : (Part I: knee)by Jie C Nguyen on 11 Giugno 2025
The classic terminology "osteochondritis dissecans (OCD)" describes a pathologic alteration, centered at the osteochondral junction, involving the subchondral bone and/or its cartilaginous precursor, with risk for lesion instability and disruption of the overlying articular cartilage. Among children and young adults, these sites of osteochondrosis can be a cause of chronic joint pain and are most often found within the knee, the ankle, and the elbow joints. No consensus exists on the precise...
- Shadows in the Air: Mental health vulnerabilities under PM10 and PM2.5, before and after COVID-19by Jae Il Cho on 10 Giugno 2025
Air pollution is an increasing public health concern, with evidence indicating that poor air quality adversely affects health through various pathways. However, its impact on mental health remains underexplored despite indications of pollutant-induced distress. This study examines the causal relationship between air pollution and mental health disorders-such as depression, sleep disorders, ADHD, and OCD-in South Korea. Assessing this relationship is challenging due to the simultaneous occurrence...
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptomsby Aleksandra Brzozowska on 13 Giugno 2025
Approximately 70% of people will experience a traumatic event in their lifetime, but post-traumatic stress disorder (PTSD) will only develop in 3.9% and complex post-traumatic stress disorder (CPTSD) in 1-8% of the population worldwide, although in some countries (e.g., Poland and Northern Ireland) it will develop in a much higher percentage. Stress-related disorders have a complex pathogenesis involving neurophysiological, genetic, epigenetic, neuroendocrine and environmental factors. This...
- Long-Term miRNA Changes Predicting Resiliency Factors of Post-Traumatic Stress Disorder in a Large Military Cohort-Millennium Cohort Studyby Ruoting Yang on 13 Giugno 2025
Post-traumatic stress disorder (PTSD) is a complex, debilitating condition prevalent among military personnel exposed to traumatic events, necessitating biomarkers for early detection and intervention. Using data from the Millennium Cohort Study, the largest and longest-running military health study initiated in 2001, our objective was to identify specific microRNA (miRNA) expression patterns associated with distinct PTSD symptom trajectories among service members and veterans and assess their...
- Stoicism or Defeat? The Psychological Impact of the Kiln Environment on Working Donkeys and Mulesby Katy Taylor on 13 Giugno 2025
One of the most problematic situations for the estimated 60 million working donkeys and mules across the world is within the brick kiln environment. In countries such as Egypt, Nepal, India and Pakistan, donkeys and mules carry dried bricks into small kilns either by pulling carts or carrying loaded packs. The health and welfare problems of this environment are well documented: they may carry excessive loads; work long hours, have difficulties accessing food, water and rest options; and can...
- Unraveling Youth Trauma and Parental Influence After Twin Earthquakesby Georgios Giannakopoulos on 13 Giugno 2025
Background: Earthquake exposure has been linked with high rates of posttraumatic stress symptoms (PTSS) and comorbid conditions. Familial factors play critical roles in modulating these outcomes. This study examined youth trauma and parental influence following the twin earthquakes in Kefalonia, Greece, in 2014; Methods: A cross-sectional study was conducted with 502 adolescents (aged 11-18 years) and 474 parents from three regions categorized by proximity to the earthquake epicenter....
- Distinctive factors contributing to psychological distress in second-generation offspring of Holocaust survivors: Posttraumatic stress and sense of coherenceby Laura Nohr on 13 Giugno 2025
The psychological impact of historical trauma can be passed on to future generations. The simultaneous presence of historical and individual trauma may increase psychological distress, especially in older adults. Older age potentially represents a phase of life with increased challenges, distress, life review, and reminiscence. Though both historical and individual trauma appear to contribute to psychological distress, a strong sense of coherence (SOC) may reduce psychological distress and...
- Effects of the After Deployment Adaptive Parenting Tools Intervention on Social Functioning in Veterans and Their Partners: A Pilot Studyby Petrus G J Janssen on 13 Giugno 2025
Deployment-related PTSD can negatively impact social functioning in veteran families. Individualized PTSD-focused therapy does not consistently lead to improved social functioning. Addressing social difficulties more directly in these families is thus important. The goal of this study was to conduct an observational pilot of the clinical effectiveness of after deployment adaptive parenting tools (ADAPT), a parenting intervention for veterans and their partners. Participants were recruited at...
- Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in Chinaby Xuanlin Li on 11 Giugno 2025
Fibromyalgia is a prevalent chronic condition marked by widespread pain, fatigue, and other debilitating symptoms. This guideline provides evidence-based recommendations for nonpharmacological treatments, developed by a multidisciplinary expert group, including specialists in rheumatology, rehabilitation, pain management, traditional Chinese medicine (TCM), and evidence-based medicine. The guideline follows the RIGHT checklist and is registered with the International Practice Guideline Registry...
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndromeby Vikas Kumar Tiwari on 25 Gennaio 2024
CONCLUSIONS: Findings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.
- Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research programby Yuliya S Nikolova on 4 Giugno 2025
Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our understanding of EFs in SUDs, including the dimensional relationships of EFs to underlying neural circuits, molecular biomarkers, disorder heterogeneity, and functional ability. Transforming health outcomes for people with SUDs requires an integration of clinical,...
- Status and trends in transcranial magnetic stimulation research: a bibliometric analysisby Qi Deng on 4 Giugno 2025
CONCLUSION: Research related to TMS has been increasing annually and is a developing field. The United States leaded the way, while Harvard University was the most active institution. Daskalakis Z.J. (Canada) was the most prolific author. The most influential journals included Brain Stimulation, Clinical Neurophysiology, and Journal of Affective Disorders. Further deep collaboration among leading countries, institutions, and authors is needed. Current hotspots in TMS research involve integration...
- Low intensity gamma-frequency TMS safely modulates gamma oscillations in probable mild Alzheimer's dementia: a randomized 2 2 crossover pilot studyby A J Mimenza-Alvarado on 30 Maggio 2025
INTRODUCTION: AD is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. While traditional treatments targeting beta-amyloid accumulation have shown limited success, there is a pressing need for novel therapeutic approaches. Recent studies have highlighted the role of disrupted gamma oscillations in AD pathology, leading to the exploration of gamma neuromodulation as a potential therapeutic strategy to modify disease progression in individuals with AD...
- Comparative efficacy, tolerability, and acceptability of aducanumab, lecanemab, and donanemab with repetitive transcranial magnetic stimulation on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysisby Itsuki Terao on 19 Maggio 2025
CONCLUSIONS: rTMS may be more effective, tolerable, and acceptable than aducanumab, lecanemab, and donanemab. Long-term direct comparison studies are needed.
- Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trialby Da Han on 20 Aprile 2025
This study evaluates the synergistic effects of transcranial magnetic stimulation (TMS) and transcranial photobiomodulation (tPBM) on working memory (WM) in mild cognitive impairment (MCI) patients. In a randomized controlled trial with 88 participants, utilizing a complex WM task (ΔK = 6.41, p = 0.004) alongside functional near-infrared spectroscopy (fNIRS) to assess cognitive performance and neural correlates(neural metrics from fNIRS indicated enhanced functional connectivity [p = 0.015] and...
- Effects of 52 weeks of precuneus rTMS in Alzheimer's disease patients: a randomized trialby Giacomo Koch on 2 Aprile 2025
CONCLUSIONS: Fifty-two weeks of PC-rTMS may slow down the impairment of cognitive functions, activities of daily living and behavioral disturbances in patients with mild-to-moderate AD. Further multicenter studies are needed to confirm the clinical potential of DMN personalized rTMS.
- When the Mind Meets the Ear: A Scoping Review on Tinnitus and Clinically Measured Psychiatric Comorbiditiesby Virginie Arsenault on 13 Giugno 2025
Background/Objectives:Tinnitus, the perception of sound without an external source, is a prevalent and often distressing condition with complex neurobiological and psychological underpinnings. A growing body of literature suggests a frequent co-occurrence between tinnitus and psychiatric symptoms such as anxiety, depression, and sleep disturbances. However, the extent to which these conditions are associated, and whether treatments targeting one domain impact the other, remains unclear. This...
- Feasibility of an App-Assisted and Home-Based Video Version of the Timed Up and Go Test for Patients with Parkinson Disease: vTUGby Marcus Grobe-Einsler on 13 Giugno 2025
Background: Parkinson Disease (PD) is a progressive neurodegenerative disorder. Current therapeutic trials investigate treatments that can potentially modify the disease course. Testing their efficiency requires outcome assessments that are relevant to patients' daily lives, which include gait and balance. Home-based examinations may enhance patient compliance and, in addition, produce more reliable results by assessing patients more regularly in their familiar surroundings. Objective: The...
- Rethinking Otorhinolaryngologic Care Pathways in Children with Down Syndrome: A Multidisciplinary Framework for Early Diagnosis and Managementby Francesco Fabrizio Comisi on 13 Giugno 2025
Background: Children with Down syndrome (DS) are at high risk for a broad spectrum of otorhinolaryngologic (ENT) disorders, including hearing impairment, obstructive sleep apnea (OSA), dysphagia, and language delay. These conditions often coexist and interact with the neurodevelopmental and anatomical features of DS, requiring early identification and coordinated management. Despite the clinical burden, ENT involvement in DS remains under-characterized and inconsistently addressed in care...
- Mechanism-Based Neuromodulation in Augmenting Respiratory Motor Function in Individuals with Spinal Cord Injuryby Farwah Fatima on 13 Giugno 2025
Spinal cord injury (SCI) is one of the most debilitating conditions that has profound effects on every physiological system, including respiratory dysfunction, which is listed among the most common causes of mortality and morbidity in this population. Previous research has demonstrated that respiratory training could facilitate respiratory motor- and autonomic activity-based plasticity. However, due to the reduced excitability of spinal networks below the level of injury, the effectiveness of...
- Outcome of Sleep Rehabilitation in Autistic Children with Sleep Disorders Is Linked to Melatonin Receptor Genes SNPsby Elisabetta Bolognesi on 13 Giugno 2025
A significant proportion of children with Autism spectrum disorder (ASD) experience sleep issues, such as insomnia and other disorders, as assessed by the Sleep Disturbance Scale for Children. Our study investigated the link between six single nucleotide polymorphisms (SNPs) in the melatonin receptor genes MT1 and MT2 and ASD susceptibility, clinical severity and associated sleep problems. A total of 139 ASD children, 82 siblings, and 53 unrelated healthy controls, all of Sardinian ancestry,...
- Circadian Disruption and Sleep Disorders in Astronauts: A Review of Multi-Disciplinary Interventions for Long-Duration Space Missionsby Hongjie Zong on 13 Giugno 2025
As humanity advances into deep space exploration, astronauts on long-duration missions face significant challenges posed by circadian rhythm disruptions and sleep disorders, which arise from extreme environmental stressors such as microgravity, ionizing radiation, and operational workload. These disruptions not only compromise physiological and psychological health but also impair cognitive function and mission-critical performance. In this review, we summarized established countermeasures...
- Subdural Hematoma Presenting with Tinnitus After Spinal Anesthesia for Cesarean Section: A Case Reportby Bülent M Çam on 13 Giugno 2025
A 35-year-old woman with a history of migraine underwent cesarean section under spinal anesthesia using a 25G Quincke needle. On postoperative day two, she developed postdural puncture headache (PDPH) and bilateral tinnitus. Although the headache resolved with intravenous fluids and theophylline, tinnitus persisted. Audiometry revealed bilateral low-frequency sensorineural hearing loss, and cranial MRI confirmed bilateral subdural hematomas (SDHs). She was treated conservatively and discharged...
- A Hybrid Digital-4E Strategy for comorbid migraine and depression: a medical hypothesis on an AI-driven, neuroadaptive, and exposome-aware approachby Parisa Gazerani on 13 Giugno 2025
CONCLUSION: A closed-loop, AI-driven neuroadaptive system could improve outcomes by enabling early detection, real-time intervention, and precision care tailored to individual neurophysiological and environmental profiles. Addressing AI bias, data privacy, and clinical validation is crucial for implementation. If validated, this Hybrid Digital-4E Strategy could redefine migraine-depression management, paving the way for precision neuropsychiatry.
- Migraine resolution in a patient receiving Cox() flexion-distraction and thoracolumbar spinal manipulative therapy: a case reportby Nicholas Linn on 13 Giugno 2025
OBJECTIVE: This case report describes the use of flexiondistraction as a chiropractic treatment for a 46-year-old woman experiencing acute-onset migraine headaches.
- RNA-seq reveals transcriptomic differences in circadian-related genes of the choroid plexus in a preclinical chronic migraine modelby Yohannes W Woldeamanuel on 12 Giugno 2025
CONCLUSION: CP transcriptomics in the rat migraine model revealed sex-specific gene regulation, with females upregulating antioxidant genes (MT2A, SLC7A11) and males upregulating inflammatory factors (ZBTB16, S100A8), alongside circadian disruption (e.g., SERPINE1 upregulated, PER2 downregulated). Pathway analyses indicate enriched circadian rhythms, HIF-1 signaling (females), inflammatory processes (males), lipid metabolism (PPARα), and heme signaling, highlighting sex-specific and circadian...
- Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and CGRP sensitizationby Eric A Kaiser on 12 Giugno 2025
CONCLUSIONS: Our findings further support that ipRGCs play a key role in mediating photophobia. This aversive response to light stems from ipRGCs combining excitatory input from intrinsic melanopsin stimulation and extrinsic L-cone input, which can be opposed by extrinsic inhibitory S-cone input. Chronic exposure to CGRP is likely one of many mechanisms in migraine that can amplify ipRGC signals, leading to photophobia.
- Daily light exposure habits of youth with migraine: A prospective pilot studyby Carlyn Patterson Gentile on 12 Giugno 2025
Photophobia is a common symptom in youth with migraine, but it is unknown if it leads to light avoidant behavior, and if such behaviors worsen disease burden. We conducted a feasibility study between November and March 2024 measuring light exposure using wearable light logger pendants in 20 youth with migraine (10-21 years old) while migraine symptoms were tracked with a text-based daily diary. On average, participants received recommended light exposure during only 14.5% +/- SD 7.0 of daylight...
- The Joint Association of Diet Quality and Sleep Regularity with Incident Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosisby Kaitlin S Potts on 13 Giugno 2025
CONCLUSIONS: Having irregular sleep and low diet quality confers the highest CVD risk compared to having neither or only one of these behaviors. These results underscore the importance of interventions targeting these unhealthy lifestyle behaviors, especially when they co-occur.
- Analysis of Blame, Guilt, and Shame Related to Body and Body Weight and Their Relationship with the Context of Psychological Functioning Among the Pediatric Population with Overweight and Obesity: A Systematic Reviewby Kamila Czepczor-Bernat on 13 Giugno 2025
Background/Objectives: There is scientific evidence showing that body- and/or body weight-related blaming, guilting, and shaming continue to be both promoted and tolerated in many societal contexts, including schools and healthcare settings. A deeply ingrained belief still prevails among many individuals that inducing these negative emotions can serve as a motivator for children and adolescents to engage in obesity treatment. Therefore, the aim of this systematic review is to examine these...
- Feeding Difficulties in Children with Hepatic Glycogen Storage Diseases Identified by a Brazilian Portuguese Validated Screening Toolby Bárbara Cristina Pezzi Sartor on 13 Giugno 2025
Background/Objectives: Hepatic glycogen storage diseases (GSDs) are inherited metabolic disorders that affect glycogen synthesis or breakdown, primarily involving the liver and muscles. Treatment typically consists of strict dietary management, including the consumption of uncooked cornstarch. However, there is limited research on feeding challenges and the associated stress experienced by parents of children with GSDs. This study aims to assess feeding difficulties in children with GSDs and the...
- Influence of Lycopene Intake on Mental Health: A Systematic Review of Randomized Controlled Trials (RCTs)by Dominika Głąbska on 13 Giugno 2025
Background/Objectives: The potential influence of lycopene on mental health was indicated in some studies, but it was not summarized within any systematic review so far. The aim of the presented study was to analyze the influence of lycopene on mental health within a systematic review of Randomized Controlled Trials (RCTs). Methods: The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and it was based on PubMed, Web of...
- The Conclusive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED): Development and Psychometric Propertiesby Moria Golan on 13 Giugno 2025
Background: Accurately assessing eating disorder (ED) severity and treatment progress is essential for effective intervention. The Comprehensive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED) was developed to address limitations in existing assessments by incorporating behavioral, cognitive, and physiological markers. Objectives: This study aimed to examine the psychometric properties and sensitivity to symptom changes of the CONTASI-ED in a...
- Does Identifying with Another Face Alter Body Image Disturbance in Women with an Eating Disorder? An Enfacement Illusion Studyby Jade Portingale on 13 Giugno 2025
Background/Objectives: Individuals with eating disorders (EDs) experience stronger body illusions than control participants, suggesting that abnormalities in multisensory integration may underlie distorted body perception in these conditions. These illusions can also temporarily reduce body image disturbance. Given the centrality of the face to identity and social functioning-and emerging evidence of face image disturbance in EDs-this study examined, for the first time, whether individuals with...
- When the Mind Meets the Ear: A Scoping Review on Tinnitus and Clinically Measured Psychiatric Comorbiditiesby Virginie Arsenault on 13 Giugno 2025
Background/Objectives:Tinnitus, the perception of sound without an external source, is a prevalent and often distressing condition with complex neurobiological and psychological underpinnings. A growing body of literature suggests a frequent co-occurrence between tinnitus and psychiatric symptoms such as anxiety, depression, and sleep disturbances. However, the extent to which these conditions are associated, and whether treatments targeting one domain impact the other, remains unclear. This...
- Predicting Cognitive Impairment in Elderly Patients with HFpEF: Development of a Simple Clinical Risk Scoreby Sergiu-Florin Arnautu on 13 Giugno 2025
Background/Objectives: Cognitive impairment is a frequent and underrecognized comorbidity in elderly patients with heart failure with preserved ejection fraction (HFpEF), contributing to poor outcomes and complicating disease management. This study aimed to identify risk factors associated with cognitive impairment in elderly HFpEF patients from Western Romania and to develop a point-based risk score for clinical use. Methods: We conducted a cross-sectional analysis of HFpEF patients aged ≥65...
- Niacin Modulates SIRT1-Driven Signaling to Counteract Radiation-Induced Neurocognitive and Behavioral Impairmentsby Erdinç Tunç on 13 Giugno 2025
Radiation exposure causes neuroinflammation, oxidative stress, and neuronal loss, leading to cognitive and behavioral impairments. This study aims to evaluate the effect of niacin interventions on whole-brain irradiation (WBI)-induced cognitive and behavioral impairment. Female Wistar rats were randomly assigned to Control (Group 1), Radiation +Saline (Group 2), and Radiation +niacin (Group 3) groups. Rats in the irradiated groups (Groups 2 and 3) received a single dose of 20 Gy photon...
- Inhibition of Ferroptosis Attenuates Neuron Damage and Improves Cognitive Impairment in Mice Surviving Severe Hypothermiaby Wei-Xuan Li on 13 Giugno 2025
Survivors of severe hypothermia frequently exhibit cognitive impairments. However, the underlying mechanisms remain inadequately understood. In order to reveal the scientific problem of cognitive dysfunction caused by severe hypothermia, providing an experimental basis for clinical treatment, this study utilized animal models and combined cognitive behavioral, morphological, and molecular biological experiments. The results showed that severe hypothermia leads to an accumulation of iron ions in...
- Imatinib attenuates neurobehavioral deficits and hippocampal neuronal damage after global cerebral ischemia in gerbilsby Hina Lateef Nizami on 13 Giugno 2025
Imatinib mesylate, a selective tyrosine kinase inhibitor, exhibited beneficial effects against various neurological diseases besides its anticancer activity. However, its effects on global cerebral ischemia in gerbils remain to be investigated. Global cerebral ischemia was induced by bilateral carotid artery occlusion (BCAO) in male Mongolian gerbils. Imatinib (3, 10, and 30 mg/kg BW) was administered intraperitoneally (i.p.) 30 min before BCAO. Imatinib (3 and 10 mg/kg) significantly...
- Suk-SaiYasna Remedy, a Traditional Thai Medicine, Mitigates Stress-Induced Cognitive Impairment via Keap1-Nrf2 Pathwayby Wuttipong Masraksa on 13 Giugno 2025
Suk-SaiYasna (SSY) is a well-documented traditional Thai herbal formula in the Royal Scripture of King Narai's Traditional Medicine. SSY contains Cannabis sativa leaves as a key ingredient and has traditionally been used to promote sleep, alleviate stress-related symptoms, and stimulate appetite. This study aimed to investigate the neuroprotective effects of SSY in a mouse model of unpredictable chronic mild stress (UCMS)-induced cognitive impairment and explore the underlying mechanisms,...
- Unveiling the role of traditional regimens in the management of uterine fibroids: A systematic reviewby Acharya Balkrishna on 12 Giugno 2025
Uterine fibroids (UF) affect 75% of women, causing pelvic discomfort, heavy bleeding, and fertility issues. Standard treatments pose risks like liver impairment and reduced bone density. Traditional medicines (TM) offer alternative approaches. We found that data from PubMed, Google Scholar, Science Direct, and bibliometric analysis using Dimension AI support TM's efficacy. In this review, we examined 21 case studies across Ayurveda, Unani, Siddha, Homeopathy, Yoga, Cupping Therapy, and...
- A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistenceby Francesco Mazziotta on 5 Giugno 2025
Relapsed and/or refractory acute myeloid leukemia (AML) post-allogeneic hematopoietic cell transplantation (HCT) is usually fatal. We previously reported that post-HCT immunotherapy with Epstein-Barr virus (EBV)-specific donor CD8^(+) T cells engineered to express a Wilms Tumor Antigen 1-specific T-cell receptor (T(TCR-C4)) appeared to prevent relapse in high-risk patients. In this phase I/II clinical trial (NCT01640301), we evaluated safety (primary endpoint), persistence and efficacy...
- Safety and efficacy of Deep TMS for adolescent depression based on large real-world data analysisby Yiftach Roth on 31 Maggio 2025
Adolescent major depressive disorder (MDD) is a prevalent and serious mental health condition. Pharmacological treatments are commonly used but often have poor tolerability and severe side effects, such as suicidal ideation. Deep transcranial magnetic stimulation (TMS) is currently cleared treating MDD in individuals 22-86 years old. This post-marketing surveillance study was designed to evaluate the safety and efficacy of using this tool as a treatment for MDD in younger patients. Data were...
- Low intensity gamma-frequency TMS safely modulates gamma oscillations in probable mild Alzheimer's dementia: a randomized 2 2 crossover pilot studyby A J Mimenza-Alvarado on 30 Maggio 2025
INTRODUCTION: AD is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. While traditional treatments targeting beta-amyloid accumulation have shown limited success, there is a pressing need for novel therapeutic approaches. Recent studies have highlighted the role of disrupted gamma oscillations in AD pathology, leading to the exploration of gamma neuromodulation as a potential therapeutic strategy to modify disease progression in individuals with AD...
- Efficacy and Safety of Transcranial Magnetic Stimulation for Treating Late-Life Depression: A Scoping Reviewby Ciprian-Ionuț Băcilă on 28 Maggio 2025
Background/Objectives: Transcranial magnetic stimulation (TMS) is a non-invasive and well-tolerated treatment, offering an effective alternative for elderly patients with depression, especially when side effects or comorbidities limit medication. Methods: This scoping review analyzes 16 studies published over the past seven years, to evaluate the efficacy, safety, and clinical applications of TMS in older adults with depression. Results: The review examines various TMS modalities, including...
- The Impact of Transcranial Magnetic Stimulation (TMS) on Depressive Symptomatology in Patients with Chronic Pain Disorders: A Systematic Reviewby Maria Inês Salgado on 27 Maggio 2025
CONCLUSIONS: The impact of TMS on depressive symptomatology among patients with chronic pain is a complex subject. Considering the diversity of the protocols and results encountered, future research should prioritize the establishment of standardized TMS protocols to clarify their efficacy in managing depressive symptoms among these patients. This systematic review highlights the need for further investigation of TMS as a dual therapeutic approach for chronic pain and depressive symptomatology,...
