Glucocorticoid signalling plays a central role in the processing of traumatic memories and contributes to adaptive and pathological responses to stress, with dysregulation frequently reported in trauma-related conditions such as post-traumatic stress disorder (PTSD). A key stage in trauma memory formation is the early consolidation window, during which aversive experiences are stabilised into long-term memory through protein synthesis and activity-dependent gene expression. To investigate how...

Individuals recovering from post-traumatic stress disorder (PTSD) often relapse due to context-induced fear memory retrieval when exposed to the same context in which they first experienced the trauma. Previous studies showed that both the ventral hippocampus CA1 (vCA1) and the dorsal hippocampus CA1 (dCA1) were involved in context-induced retrieval of fear memories. However, the causal relationship and the neural circuits between vCA1 and dCA1 during this process remain unknown. The present...

CONCLUSION: The Swara-informed autonomic matching model provides a culturally grounded framework that hypothesizes how nostril-specific breathing may be integrated into psychotherapy and provides a basis for future empirical investigation. We formulated testable hypotheses and study designs to investigate whether state-matched UNB yields greater benefits than slow-paced breathing. Finally, we discuss several potential limitations, safety issues, and ethical considerations relevant to this...

Background: Persistent armed conflict in eastern Democratic Republic of the Congo has resulted in large-scale population displacement, exposing many children to traumatic experiences. Although the psychological consequences of such exposure are well documented, its impact on psychomotor development remains insufficiently investigated, particularly in African settings affected by chronic violence.Objective: This study aimed to compare the psychomotor development of displaced children living in...

There is a need for new effective treatment options for posttraumatic stress disorder (PTSD), as many people with PTSD do not fully recover despite current treatments. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy (MDMA-AT) is emerging as a new treatment option. We assessed the current body of MDMA-AT evidence for effectiveness in treating PTSD, associated impairments, and quality of life by conducting a systematic review and meta-analysis of randomized controlled trials....

CONCLUSIONS: Trauma history, decreased desire, and somatic pain significantly impact distress and should be screened for. Dyspareunia independently predicts distress but may be masked by other factors. The attenuation of depression and anxiety after multivariable adjustment may reflect shared clinical variance rather than independent drivers of distress. Overall, multidisciplinary teams including mental health, physical therapy, and social support should be included in treating sexual distress....