AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Intermittent theta burst stimulation over the left prefrontal cortex: no additional effect for virtual reality exposure therapy in acrophobia-a randomized trialby L M Cybinski on 28 Novembre 2024
Anxiety disorders are the most prevalent mental health conditions. Besides psycho-pharmacotherapy, cognitive behavioral therapy with an exposure-based approach is considered the gold standard. However, not all patients benefit from this approach. Here, we aimed to translate laboratory findings on enhanced fear extinction with repetitive transcranial magnetic stimulation (TMS) to the clinic. In this double-blind, randomized, placebo-controlled clinical trial, 76 participants with acrophobia...
- Exploring the connectivity of dorsolateral prefrontal cortex and the modulatory impact of transcranial magnetic stimulation in adolescents with depression: a focus on pain-related cognitive processingby Dan Qiao on 28 Novembre 2024
CONCLUSION: Our results point to a key role of DLPFC acting as a connection linking cognitive control and pain processing in adolescents with depression.
- Persistent adaptations in sensorimotor interneuron circuits in the motor cortex with a history of sport-related concussionby Kara D Hayes on 28 Novembre 2024
Recent studies highlight a persistent increase in subsequent injury risk following a sport-related concussion (SRC) despite clinical recovery. However, markers of persistent alterations in sensorimotor integration have yet to be identified. One possibility is that compensatory adaptation following SRC may only be unmasked during transient periods of high task complexity in specific sensorimotor circuits. The current study used short-latency afferent inhibition (SAI) to investigate the long-term...
- Single High-Frequency Repetitive Transcranial Magnetic Stimulation and Intermittent Theta Pulse Stimulation Promote Working Memory Behavior in Participants: An Event-Related Potential Studyby Longting Hu on 28 Novembre 2024
CONCLUSION: Single sessions of HF-rTMS and iTBS on the L-DLPFC specifically enhanced working memory performance, with no significant effects on executive function and visuospatial attention. Both true stimulations elicited more negative N2 in the frontal and central channels during the 2-back paradigm, suggesting increased recruitment of cognitive resources from these brain areas. Although iTBS and HF-rTMS improved working memory behavior, iTBS's shorter stimulation time suggests it may have...
- Harnessing Brain Plasticity: The Therapeutic Power of Repetitive Transcranial Magnetic Stimulation (rTMS) and Theta Burst Stimulation (TBS) in Neurotransmitter Modulation, Receptor Dynamics, and Neuroimaging for Neurological Innovationsby Minoo Sharbafshaaer on 27 Novembre 2024
Transcranial magnetic stimulation (TMS) methods have become exciting techniques for altering brain activity and improving synaptic plasticity, earning recognition as valuable non-medicine treatments for a wide range of neurological disorders. Among these methods, repetitive TMS (rTMS) and theta-burst stimulation (TBS) show significant promise in improving outcomes for adults with complex neurological and neurodegenerative conditions, such as Alzheimer's disease, stroke, Parkinson's disease, etc....
- Probing the orientation specificity of excitatory and inhibitory circuitries in the primary motor cortex with multi-channel TMSby Victor H Souza on 27 Novembre 2024
CONCLUSION: SICI and ICF orientation sensitivity exhibit a complex dependence on the conditioning stimulus orientation, which might be explained by anatomical and morphological arrangements of inhibitory and excitatory neuronal populations.
- Pharmacological investigation of natural compounds for therapeutic potential in neuropathic painby Muhammad Faheem on 3 Dicembre 2024
The present research is based on the investigation of post treatment naturally occurring compounds berbamine (BBM), bergapten (BRG) and carveol (CAR) in relation to its therapeutic effect in neuroinflammation and chronic constriction injury induced neuropathic pain (CCI-NP). The drug-likeness of the compounds was explored by SwissADME (http://www.swissadme.ch/). Docking was performed by Auto dock, PyRx and Discovery Studio Visualiser 2016 against cyclooxygenase-2 (COX-2) (PDB ID: ICX2), tumour...
- Ultrasound-guided perineural intercostal autologous platelet-rich plasma in the treatment of chronic post-thoracotomy pain syndrome - A prospective case seriesby César Gracia-Fabre on 3 Dicembre 2024
CONCLUSIONS: This prospective consecutive case series suggests that autologous platelet-rich plasma may offer a promising adjunctive therapy for chronic post-thoracotomy pain syndrome. However, limitations including the lack of a control group and small sample size underscore the need for further research to establish the efficacy and optimize the application of platelet-rich plasma in managing post-thoracotomy pain syndrome.
- Astilbin exerts anti-hypersensitivity by regulating metabolic demand and neuronal activity in rodent model of neuropathic painby Qiru Wang on 3 Dicembre 2024
CONCLUSIONS: In summary, this study provides evidence that astilbin alleviates pain by modulating neuronal metabolic processes and synaptic homeostasis.
- Assessment of pain prevalence in cancer patients undergoing anticancer treatments and in cancer survivors after completion of anticancer treatments: A French nationwide cross-sectional studyby Charles Ragusa on 3 Dicembre 2024
Pain is a common and disabling symptom of cancer and its treatment. This study aimed to provide an update on the prevalence, characteristics, and impact of pain on quality of life (QoL) in cancer patients and survivors in France. Data were collected using self-assessment questionnaires as part of a nationwide web-based survey conducted between January and March 2023. Pain was reported by 44.7% of the study population (n = 1029), including by 49.2% (95% CI [44.8; 53.6]) of cancer patients (n =...
- rTMS and TENS Relieve Neuropathic Pain in CCI Model Rats by Modulating Central Nervous System TRPV1 and Neuroinflammationby Zhangyu Xu on 2 Dicembre 2024
Background: Repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex (PFC) and transcutaneous electrical nerve stimulation (TENS) have both been demonstrated as effective at alleviating neuropathic pain (NP). However, the comparative efficacy of these two neuromodulation techniques and the specific neural mechanisms underlying their effects remain unclear. Objective: This study aims to compare the efficacy of rTMS in the PFC and TENS in mitigating peripheral NP and to...
- The Experience Sampling Method in Small Fiber Neuropathy: The Influence of Psychosocial Factors on Pain Intensity and Physical Activityby Aysun Damci on 2 Dicembre 2024
CONCLUSION: In idiopathic SFN, pain intensity, and physical activity showed a 2-sided association, influenced by catastrophic thoughts, fatigue, affective states, and avoidance behavior.
- Perceptions and Needs for a Technology-Based Dyadic Intervention on Symptom Management Among Patients With Colorectal Cancer and Their Caregivers: A Qualitative Studyby Amruta Epari on 3 Dicembre 2024
CONCLUSIONS: Our findings provide novel insights into experiences, needs, and suggestions of CRC patient-caregiver dyads for managing multiple symptoms. Participants emphasized the importance of developing a tailored, technology-based tool that includes personalized, evidence-based content; accessible and intuitive design features; and interactive social support capabilities.
- Effect of Self-efficacy, Disease Perception, Social Support, Anxiety, and Depression on Self-management in Young Patients With Strokeby Rongfang Zhang on 3 Dicembre 2024
BACKGROUND: Better self-management of chronic diseases may benefit patient functional status, medication effectiveness, lifestyle, and psychosocial health. Self-efficacy, disease perception, social support, anxiety, and depression are determinants of self-management behaviors in individuals with chronic illnesses. There remains a gap in the empirical exploration of the influence of these factors on self-management behaviors in young Chinese stroke survivors. This study examined how these factors...
- An initial test of a new self-guided internet-based intervention for social anxiety: iExposureby Mikael Rubin on 3 Dicembre 2024
Social anxiety is a prevalent mental health concern that impacts approximately 12% of the US population. There is a need for targeted mechanism-focused interventions for social anxiety that are also highly scalable. Using a recently developed naturalistic paradigm with simulated teleconferencing interactions as the central treatment element, we developed a new self-guided internet-based intervention for social anxiety called iExposure. This randomized clinical trial aimed at testing two...
- Psychological Symptom Cluster Severity Profiles Are Associated With Higher Levels of Stress and Worse Quality of Life in Postmenopausal Women With Breast Cancerby Carolyn S Harris on 3 Dicembre 2024
CONCLUSIONS: PSC severity is associated with higher posttraumatic stress and poorer QOL following breast surgery. Sleep disturbance is a common problem and may be undertreated.
- Research on the relationship between virtual social interaction and the degree of loneliness based on algorithm matching technologies: A quantitative analysis on the SOUL APP-A virtual social software for strangersby Linsha Liu on 3 Dicembre 2024
This study examines the relationship between virtual social interaction and people's social behaviors and psychology using algorithm matching technologies and questionnaire surveys. The focus is on interpersonal communication on virtual social platforms. The findings indicate that engaging in virtual social networking is often accompanied by a high level of loneliness. Users who experience social anxiety in the real world tend to feel more lonely, and this loneliness is exacerbated by presenting...
- The Efficacy of Virtual Reality-Based Interventions on Pain, Anxiety, Depression, and Quality of Life Among Patients With Cancer: A Meta-analysis of Randomized Controlled Trialsby Yang Chen on 3 Dicembre 2024
CONCLUSIONS: Virtual reality-based interventions are effective at decreasing pain and anxiety. The contents and duration of the intervention had an impact on their effectiveness.
- Cognitive behavioural therapy for internalizing symptoms in LGBTQ+ people: a preliminary meta-analysisby Isaac B J M D Dunn on 3 Dicembre 2024
Internalizing disorders are common in lesbian, gay, bisexual, transgender, queer, questioning, and otherwise non-heterosexual or non-cisgender (LGBTQ+) people. Few studies have evaluated the efficacy of cognitive behavior therapy (CBT), a well-established treatment for internalizing disorders, in LGBTQ+ people. The current study quantitatively synthesized outcomes from existing trials of CBT for internalizing disorders in LGBTQ+ people. Seven databases were searched, identifying 14 relevant...
- Depression Symptoms Do Not Worsen Over Time in a Cohort of CKD Patients: The BRINK Studyby Christopher D Knapp on 3 Dicembre 2024
CONCLUSIONS: The mean PHQ-9 scores of participants were largely stable over time, and we observed no differences in the change in PHQ-9 scores between those with impaired eGFR and those with normal eGFR.
- Perceptions and Needs for a Technology-Based Dyadic Intervention on Symptom Management Among Patients With Colorectal Cancer and Their Caregivers: A Qualitative Studyby Amruta Epari on 3 Dicembre 2024
CONCLUSIONS: Our findings provide novel insights into experiences, needs, and suggestions of CRC patient-caregiver dyads for managing multiple symptoms. Participants emphasized the importance of developing a tailored, technology-based tool that includes personalized, evidence-based content; accessible and intuitive design features; and interactive social support capabilities.
- Effect of Self-efficacy, Disease Perception, Social Support, Anxiety, and Depression on Self-management in Young Patients With Strokeby Rongfang Zhang on 3 Dicembre 2024
BACKGROUND: Better self-management of chronic diseases may benefit patient functional status, medication effectiveness, lifestyle, and psychosocial health. Self-efficacy, disease perception, social support, anxiety, and depression are determinants of self-management behaviors in individuals with chronic illnesses. There remains a gap in the empirical exploration of the influence of these factors on self-management behaviors in young Chinese stroke survivors. This study examined how these factors...
- Association of Lipoprotein-Associated Phospholipase A2 and Lipoprotein(a) With the Risk of Recurrence Stroke in Patients With Acute Ischemic Strokeby Yu Feng on 3 Dicembre 2024
CONCLUSION: This investigation underscores the potential advantage of leveraging the combined impact of Lp-PLA2 in conjunction with Lp(a) as a more precise and cost-effective predictive tool for the risk of recurrence stroke in patients with AIS.
- Psychological Symptom Cluster Severity Profiles Are Associated With Higher Levels of Stress and Worse Quality of Life in Postmenopausal Women With Breast Cancerby Carolyn S Harris on 3 Dicembre 2024
CONCLUSIONS: PSC severity is associated with higher posttraumatic stress and poorer QOL following breast surgery. Sleep disturbance is a common problem and may be undertreated.
- Zur Diskussion / Up for Discussion. Gefährdet die Cannabislegalisierung Kinder und Jugendliche? / Does Cannabis Legalization Endanger Children and Adolescents?by Rainer Thomasius on 3 Dicembre 2024
Does Cannabis Legalization Endanger Children and Adolescents? The Cannabis Act (CanG) came into force on April 1, 2024. It regulates the "controlled supply of cannabis to adults for recreational purposes". In the USA, legalization has contributed to a decrease in the risk perception of the health hazards of consumption and an increase in risky consumption patterns, including among adolescents. The use of cannabis-related emergency and addiction treatment has risen sharply. Similar developments...
- Originalarbeiten / Original Articles. Prävention akuter Alkoholintoxikationen bei Kindern und Jugendlichen: Trinkumstände und Empfehlungen aus Sicht betroffener Eltern und Jugendlicher / Prevention of Acute Alcohol Intoxication in Children and Adolescents: Drinking Circumstances and Recommendations from the Perspective of Affected Parents and Adolescentsby Silke Diestelkamp on 3 Dicembre 2024
Prevention of Acute Alcohol Intoxication in Children and Adolescents: Drinking Circumstances and Recommendations from the Perspective of Affected Parents and Adolescents Alcohol consumption among children and adolescents in Germany is showing a downward trend. However, a significant number of minors reports risky drinking patterns that lead to alcohol intoxication requiring inpatient treatment. Findings on drinking circumstances that precede alcohol intoxication and on rules on alcohol...
- Übersichtsarbeiten / Review Articles. Die Computerspielstörung in der ICD-11: Hintergründe, Kriterien und mögliche Implikationen / Gaming Disorder According to the ICD-11: Background, Criteria and Possible Implicationsby Martin Fuchs on 3 Dicembre 2024
Gaming Disorder According to the ICD-11: Background, Criteria and Possible Implications Within 60 years, playing computer games - online or offline, with a computer, games console or smartphone - has developed from a niche activity for mostly young males into a global industry worth billions. Studies show that children and adolescents in particular tend to play digital games for several hours a day, making gaming one of the most common leisure activities for young people. A small proportion of...
- Zur Diskussion / Up for Discussion. Schützt Cannabis-Strafverfolgung die Gesundheit junger Menschen? Zur Umsetzung des Cannabisgesetzes / Does Cannabis Prosecution Protect Young People's Health? On the Implementation of the Cannabis Actby Nadja Gaßmann on 3 Dicembre 2024
Does Cannabis Prosecution Protect Young People's Health? On the Implementation of the Cannabis Act Different drug policy alternatives involve their respective opportunities and risks. When weighing up the options, a large number of stakeholders concluded that criminal prosecution of cannabis protects the bio-psycho-social health of young people less than decriminalisation. They demanded and welcome the new regulation of cannabis, also in terms of the protection of minors. The extent to which the...
- Methylphenidate abuse and misuse in patients affected with a psychiatric disorder and a substance use disorder: a systematic reviewby Stefania Chiappini on 3 Dicembre 2024
CONCLUSION: MPH misuse and abuse are significant concerns in patients with psychiatric disorders and SUD. Risk factors include impulsivity, history of substance abuse, and access to prescription stimulants. Integrated therapeutic approaches and stricter prescription monitoring are recommended to mitigate misuse risks.
- Project SCOPE: a National Training Initiative to improve capacity of providers to support children impacted by prenatal opioid exposure using the ECHO model™by Stephanie Weber on 3 Dicembre 2024
INTRODUCTION: Neonatal abstinence syndrome (NAS) is a complex condition resulting from prenatal substance exposure that has become increasingly prevalent as a result of the opioid epidemic. NAS can lead to long-term developmental challenges. Interdisciplinary teams with experience working with children with disabilities that focus on social determinants of health can be effective at supporting families affected by NAS. Unfortunately, interdisciplinary teams often lack sufficient training,...
- Methylphenidate abuse and misuse in patients affected with a psychiatric disorder and a substance use disorder: a systematic reviewby Stefania Chiappini on 3 Dicembre 2024
CONCLUSION: MPH misuse and abuse are significant concerns in patients with psychiatric disorders and SUD. Risk factors include impulsivity, history of substance abuse, and access to prescription stimulants. Integrated therapeutic approaches and stricter prescription monitoring are recommended to mitigate misuse risks.
- What Is Pink Cocaine? The Dark Reality behind a Colorful Nameby Lisa Barbaro on 3 Dicembre 2024
No abstract
- Oxytocin reduces methylphenidate-induced dorsal striatal dopamine release in male rhesus macaquesby Mary R Lee on 3 Dicembre 2024
CONCLUSION: The results provide translational and mechanistic evidence for the potential role of oxytocin as a treatment for psychostimulant use disorders.
- Technology-Based Interventions for Substance Use Treatment Among People Who Identify as African American or Black, Hispanic or Latino, and American Indian or Alaska Native: Scoping Reviewby Sarah K Moore on 3 Dicembre 2024
CONCLUSIONS: While the prevalence of TBIs in substance use treatment has increased recently, studies that include and consciously consider URM groups are rare, especially for American Indian or Alaska Native and Hispanic or Latino groups. This review highlights the limited research on TBIs in substance use treatment that promotes racial and ethnic health equity and provides context, insights, and direction for researchers working to develop and evaluate digital technology substance use...
- Near-Fatal Aspiration of Drug Contrabandby Don M Benson on 2 Dicembre 2024
This case report describes a near-fatal airway obstruction in a woman attempting to conceal drug contraband in her mouth. A patient was brought to the emergency department by emergency medical services accompanied by police after she had refused to open her mouth after being detained. The patient was initially seen at triage, being awake and responsive, but still refusing to open her mouth. While in the emergency department, she rapidly deteriorated exhibiting signs of upper airway obstruction....
- Venlafaxine treatment is associated with improved mood, but not decreased cocaine self-administration, in depressed people who use cocaineby Rebecca L Chalmé on 1 Dicembre 2024
Individuals seeking treatment for their cocaine use often report depressive systems and nearly half meet criteria for major depressive disorder (MDD). This descriptive study aimed to assess the effects of the antidepressant venlafaxine alone and in combination with gabapentin on depressive symptoms, subjective effects of cocaine, and cocaine self-administration in depressed and non-depressed people who use cocaine. The effects of medication condition on mood and on the effects of smoked cocaine...
- Übersichtsarbeiten / Review Articles. Die Computerspielstörung in der ICD-11: Hintergründe, Kriterien und mögliche Implikationen / Gaming Disorder According to the ICD-11: Background, Criteria and Possible Implicationsby Martin Fuchs on 3 Dicembre 2024
Gaming Disorder According to the ICD-11: Background, Criteria and Possible Implications Within 60 years, playing computer games - online or offline, with a computer, games console or smartphone - has developed from a niche activity for mostly young males into a global industry worth billions. Studies show that children and adolescents in particular tend to play digital games for several hours a day, making gaming one of the most common leisure activities for young people. A small proportion of...
- Safety and efficacy of ruxolitinib cream for the treatment of vitiligo: A randomised controlled trial secondary analysis at 3 yearsby John E Harris on 3 Dicembre 2024
No abstract
- A case of Mycoplasma pneumoniae-induced rash and mucositis with recent influenza vaccinationby Vani Agarwal on 3 Dicembre 2024
A 33-year-old female presented with coryzal symptoms, facial swelling, severe haemorrhagic stomatitis, blistering oral mucositis, conjunctival injection and a sparse targetoid rash on the back and face, requiring admission to hospital. She had received the seasonal influenza vaccination 3 days prior to feeling unwell. Differential diagnosis included erythema multiforme major (EMM) secondary to the influenza vaccine or Mycoplasma pneumoniae-induced rash and mucositis (MIRM). Oropharyngeal swabs...
- Watch and yearn? Effects of watching gambling livestreams on cravingsby Raymond Wu on 3 Dicembre 2024
BACKGROUND: Gambling content on streaming platforms has gained popularity. Given their intense, cue-laden nature, watching gambling streams may trigger cravings among viewers. At the same time, people who gamble may be motivated to watch gambling streams in an attempt to regulate their cravings.
- The National Joint Registry Data Quality Audit of elbow arthroplastyby Zaid Hamoodi on 2 Dicembre 2024
CONCLUSION: The rate of completeness of the NJR total elbow arthroplasty dataset is currently 93% and the accuracy is 98%. This audit identified challenges of data capture with regard to RHAs. Collaboration with a trauma and orthopaedic trainees through the British Orthopaedic Trainee Association improved the completeness and accuracy of the NJR elbow dataset, which will improve the validity of the reports and of the associated research.
- Effects of Dialectical Behavior Therapy on Cognitive and Executive Functions in Men With Substance Use Disorder Under Methadone Maintenance Treatment: A Randomized Clinical Trialby Kiamars Khezrian on 2 Dicembre 2024
Substance use disorder is a major public health problem, and its treatment is one of the most challenging issues facing clinical professionals. This clinical trial study investigated the effects of the dialectical behavior therapy (DBT) on cognitive and executive functions in patients under methadone maintenance treatment (MMT). Participants included 50 people under MMT who referred to addiction treatment clinics in Kashan in 2018. They were randomly assigned to intervention (DBT + MMT) and...
- Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric populationby Michelle Sader on 3 Dicembre 2024
CONCLUSIONS: This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition.
- Gut Microbiota Regulates Food Intake in a Rodent Model of Intermittent Limited Access to Palatable Foodby Thomas Demangeat on 3 Dicembre 2024
OBJECTIVE: Binge-eating disorder is characterized by recurrent episodes of consumption of large amounts of food within a short period of time, without compensatory purging behaviors. This disease is a major public health issue and is associated with numerous comorbidities, encompassing anxiety and depression. The gut microbiota has been proposed to be an important player in the onset or maintenance of eating disorders. Here, we aim to better delineate the potential role of the gut microbiota in...
- Therapists' perspectives on the Maudsley model anorexia nervosa treatment for adolescents and young adults (MANTRa): A qualitative interview studyby Michael Zeiler on 3 Dicembre 2024
CONCLUSIONS: The findings suggest how the MANTRa content (e.g. inclusion of additional therapeutic tools), the therapists' training and the format (e.g. provision of a digital version) can be improved to reach maximum impact. Therapists' formulation letters may be an effective therapeutic tool not only for AN but also across the spectrum of psychiatric disorders in adolescents and young adults.
- Virtual Reality as an Innovative Tool for Eating Disorders Psychological Treatmentby Abdulnaser Fakhrou on 3 Dicembre 2024
CONCLUSION: This review highlights how VR, with its specific characteristics, serves as an excellent ally to enhance both assessment and treatment for EDs. Future research should focus on filling existing gaps and delving into aspects not yet explored. One potential development could involve creating guidelines for VR use in EDs.
- Adverse Neonatal Outcomes Among Children Born to Mothers Eating Disorders: A Register-Based Cohort Studyby Hannah Chatwin on 2 Dicembre 2024
CONCLUSIONS: Children born to mothers with EDs have an increased risk of some adverse neonatal outcomes, with more pronounced risks in recent than past EDs. These results underscore the need for improved prevention of maternal EDs and enhanced monitoring throughout pregnancy to mitigate adverse outcomes.
- Navigating (Dis)empowerment: Dialectical Tensions in the Enactment of Resilience of College Students with Eating Disordersby Meina Liu on 2 Dicembre 2024
Research has shown a dramatic increase of eating disorders (EDs) among young people during disruptive times. Understanding the role of communication in impeding or enacting resilience not only helps those with EDs develop better strategies for coping and changing their lives but can also inform effective interventions at familial, community, and system levels. Guided by the communication theory of resilience (CTR), our study explores how college students with EDs enacted resilience through...
- Mental disorder diagnoses and symptoms and functional impairment in school-age children in the care of child protective servicesby Sebastien Monette on 2 Dicembre 2024
CONCLUSIONS: This study provides a picture of the mental disorders and symptoms among samples of school-age children in the care of child protective services and raises questions about the proportions of some of the diagnosis that children receive.
- Effect of serratus anterior plane block combined with oxycodone for transition analgesia on preventing emergence agitation after video-assisted thoracoscopic surgery: a randomized controlled trialby Tao Wang on 2 Dicembre 2024
Emergence agitation (EA) is more commonly observed after thoracic surgeries and can lead to serious complications. This study aimed to evaluate the effectiveness of serratus anterior plane block (SAPB) combined with oxycodone for transitional analgesia in preventing EA after video-assisted thoracoscopic surgery (VATS). A total of 121 adult patients scheduled for VATS under one-lung ventilation anesthesia were enrolled and randomly divided into three groups: preoperative SAPB without opioids for...
- Amphiphysin and GAD65 IgG antibodies in patients with obsessive-compulsive syndromesby Katharina von Zedtwitz on 1 Dicembre 2024
No abstract
- Psychedelics for the Treatment of Obsessive Compulsive Disorder: Efficacy and Proposed Mechanismsby Helen M Collins on 29 Novembre 2024
Psychedelics are emerging as potential treatments for a range of mental health conditions, including anxiety and depression, treatment-resistant depression, and substance use disorders. Recent studies have also suggested that the psychedelic psilocybin may be able to treat obsessive compulsive disorder (OCD). Since the 1960s, case studies have reported improvements to obsessive and compulsive behaviours in patients taking psychedelics recreationally. The effects of psilocybin were then...
- Polysomnographic changes of obsessive-compulsive disorder: evidence from case-control studiesby Yuru Nie on 29 Novembre 2024
CONCLUSIONS: Significant polysomnographic changes are present in OCD. Our findings underscore the need for a comprehensive PSG assessment of sleep changes in patients with OCD.
- TMS-evoked potentials provide novel neurophysiological features of Tourette syndromeby Simon Lassman on 29 Novembre 2024
CONCLUSION: Distinct TEP patterns registered in response to DLPFC, M1, and V1 stimulation may shed light on the underlying pathophysiology of TS and are associated with tic severity and comorbidities.
- The Moderating Role of Demoralization on the Association Between Exposure to War and Posttraumatic Stress Symptoms Among Israeli Civilians in Reaction to the October 7 War: A Longitudinal Studyby Wafaa Sowan on 3 Dicembre 2024
CONCLUSION: Demoralization symptoms and PTSS are likely to occur during wartime. However, war exposure alone does not explain PTSS; it is contingent on demoralization levels. Demoralization shortly following the outbreak of war appears to be a predictor of PTSS. This finding suggests that screening for demoralization with a brief simple questionnaire might be a useful clinical tool to identify individuals in the short term who may have increased risk of PTSD in the long term.
- Lived experiences of mothers: A longitudinal study of impacts and adjustment following adolescent psychiatric hospitalization for suicide attempts or other reasonsby David B Goldston on 3 Dicembre 2024
CONCLUSIONS: This study highlights the mental health struggles of mothers of suicidal and other hospitalized youth and underscores the importance of support for caregivers.
- Guilt-and Shame-Proneness, Birth-related Post-traumatic Stress and Post-Traumatic Growth in Women with Preterm Birthby Gabija Jarašiūnaitė-Fedosejeva on 3 Dicembre 2024
Mothers of premature infants are at high risk of experiencing birth trauma and poor postpartum mental health. However, for some, this experience can lead to personal growth. This study examines Lithuanian women with preterm births, where birth-related PTSD is notably higher despite a lower preterm birth rate. Given the common emotional responses of guilt and shame, we explore whether proneness to these emotions moderates the relationship between birth-related PTSD and post-traumatic growth. A...
- Personalizing cognitive processing therapy with a case formulation approach to intentionally target impairment in psychosocial functioning associated with PTSDby T E Galovski on 3 Dicembre 2024
Posttraumatic stress disorder (PTSD) is a debilitating condition often accompanied by significant functional impairments affecting quality of life and well-being. While Cognitive Processing Therapy (CPT) is a leading, evidence-based psychotherapy for PTSD, demonstrating substantial efficacy in core symptom reduction, its impact on psychosocial functioning is less well-established. The Personalizing Cognitive Processing Therapy with a Case Formulation Approach (Personalizing Approaches to...
- Pandemic-Related Stress Increases PTSD and Depression Risk in Traumatic Injury Patients: A Comparative Study of Pre- and Peri-Pandemic Trauma Casesby Juan Pablo Zapata on 3 Dicembre 2024
The COVID-19 pandemic significantly impacted the psychological well-being of the general population. However, there are limited studies that examine its mental health effects on patients who have experienced traumatic injuries and tracked their recovery over time. This study aimed to: (1) compare the rates and severity of post-traumatic stress disorder (PTSD) and depression between patients who sustained traumatic injuries before the COVID-19 pandemic (pre-pandemic) and those injured during the...
- Treatment of posttraumatic nightmares: the role of imagery rehearsal therapyby Lucile Monnier on 3 Dicembre 2024
THE ROLE OF IMAGERY REHEARSAL THERAPY. Post -traumatic stress disorder develops in 30% of adults exposed to a traumatic event. In these patients, sleep disturbances are the earliest and most persistent symptoms, but they remain relatively unresponsive to the usual treatments used in post-traumatic stress disorder. Post-traumatic nightmares are relivings of the traumatic event and a source of significant emotional distress. They concern over 70% of patients with post-traumatic stress disorder....
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndromeby Vikas Kumar Tiwari on 25 Gennaio 2024
CONCLUSIONS: Findings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.
- TMS in combination with a pain directed intervention for the treatment of fibromyalgia - A randomized, double-blind, sham-controlled trialby Einat Tilbor on 27 Dicembre 2023
CONCLUSION: Our results suggest that a course of dTMS combined with a pain-directed psychotherapeutic intervention can alleviate pain symptoms in FMS patients. Beyond clinical possibilities, future studies are needed to substantiate the innovative hypothesis that it is not dTMS alone, but rather dTMS-induced plasticity of pain-related networks, that enables the efficacy of pain-directed psychotherapeutic interventions.
- Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorderby Jiaxin Li on 16 Novembre 2024
CONCLUSION: The results of this study indicate that cortical dysfunction and cognitive impairment are present in patients with MDD and that there is a strong correlation between them, suggesting that TEPs detected by the TMS-EEG may be used as a biomarker for MDD patients and their cognitive impairment.
- Evaluating Repetitive Transcranial Magnetic Stimulation for Neuropsychiatric Symptoms in Long COVID: A Case Seriesby Jonathan Bock on 12 Novembre 2024
CONCLUSION: This case series suggests that rTMS may offer symptomatic relief in long COVID patients. Although the observed improvements in PROMIS were not statistically significant, even minimal improvements are clinically significant for patients enduring prolonged suffering. These preliminary findings are encouraging and underscore the need for further research with larger cohorts to validate the efficacy of rTMS in long COVID symptom relief.
- Functional Connectome Controllability in Patients with Mild Cognitive Impairment after Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortexby Simone Papallo on 28 Settembre 2024
Background: Repetitive transcranial magnetic stimulation (rTMS) has shown therapeutic effects in neurological patients by inducing neural plasticity. In this pilot study, we analyzed the modifying effects of high-frequency (HF-)rTMS applied to the dorsolateral prefrontal cortex (DLPFC) of patients with mild cognitive impairment (MCI) using an advanced approach of functional connectome analysis based on network control theory (NCT). Methods: Using local-to-global functional parcellation, average...
- Breakdown of TMS evoked EEG signal propagation within the default mode network in Alzheimer's diseaseby Michele Maiella on 27 Settembre 2024
CONCLUSIONS: TMS-EEG in AD shows both local hyperexcitability and a lack of signal propagation within the DMN. These neurophysiological features also correlate with structural and cognitive attributes of the patients.
- Comparative efficacy of non-invasive brain stimulation on cognition function in patients with mild cognitive impairment: A systematic review and network meta-analysisby Hong Liu on 20 Settembre 2024
CONCLUSION: The present findings provide evidence of the benefits of NIBS, especially TMS stimulating the bilateral dorsolateral prefrontal cortex, for the beneficial effect on cognitive and language function in patients with MCI. However, because few studies were available for inclusion, additional well-designed, large-scale RCTs are warranted to support exploring longer-term dynamic effects.
- Neurophysiological methods for assessing and treating cognitive impairment in multiple sclerosis: A scoping review of the literatureby Alessandro Cruciani on 19 Settembre 2024
In recent years, there has been a growing interest in exploring the non-classical symptoms of multiple sclerosis (MS), with a particular focus on cognitive impairments associated with the disease's progression. These cognitive symptoms are now recognized as crucial elements in the assessment of disease activity. In this context, neurophysiology has emerged as a valuable and accessible tool for studying and addressing cognitive decline in individuals with MS. This scoping literature review...
- The effect of sulthiame on potential biomarkers in moderate to severe obstructive sleep apnoeaby Erik Hoff on 3 Dicembre 2024
CONCLUSIONS: STM treatment in OSA induced a reduction of both CA activity and HIF-1α concentration. The effects remained 2 weeks after treatment completion, suggesting prolonged effects of STM in OSA.
- Achieving adherence to positive airway pressure in commercial drivers using an employer-mandated remote management programmeby Elizabeth Kneeland on 3 Dicembre 2024
BACKGROUND: Obstructive sleep apnoea (OSA) is common in commercial drivers, and associated with increased risk of crashes if untreated, making diagnosis and effective treatment crucial in this population.
- The Usefulness of New Body Indices in Determining the Risk of Cardiovascular Disease in Cases with Obstructive Sleep Apnea Syndromeby Mihrican Yeşildağ on 3 Dicembre 2024
CONCLUSION: BRI, one of the new indices, is a useful anthropometric parameter in the CVR assessment of OSAS patients, offering better predictive ability than traditional measurements.
- Cost-utility and clinical outcome analysis of surgery or oral corticosteroids treatment in patients with chronic rhinosinusitis with nasal polypsby Jing Zhang on 3 Dicembre 2024
CONCLUSIONS: Both surgical and oral corticosteroid treatments effectively improved clinical symptoms and quality of life in patients with CRSwNP. Patients who underwent surgery exhibited greater improvements in sinus-related symptoms. Nevertheless, oral corticosteroid treatment presented notable advantages in terms of economic cost and duration cost of disease-related care.
- Advances in Multimodal Echocardiographic Evaluation of Ischemic Cardiomyopathy due to Obstructive Sleep Apnea Syndromeby Xiaobo Yan on 3 Dicembre 2024
Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent complete (apneas) and partial (hypopneas) upper airway events, causing intermittent hypoxemia and sleep fragmentation. It significantly impacts the cardiovascular system, increasing the morbidity and mortality associated with various complications. Therefore, employing appropriate echocardiographic methods to assess myocardial function in OSAS patients is crucial. It can facilitate early clinical intervention, enhance the...
- Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controlsby Xiaoli Ouyang on 3 Dicembre 2024
CONCLUSION: ILD patients experience a higher prevalence and more severe impact of fatigue and EDS than healthy individuals, with associated factors including chest pain, diminished exercise capacity, and age. Pulmonary rehabilitation and evaluation and intervention of factors associated with fatigue and EDS such as pain, and diminished exercise capacity in ILD patients may help to improve the quality of life.
- Association between family income to poverty ratio and severe headache/migraine in the American adults: data from NHANES 1999-2004by Lingling Sun on 3 Dicembre 2024
CONCLUSION: There is a negative correlation between PIR and the incidence of severe headaches/ migraine in Americans aged 20 years or older. This study has implications for the comprehensive management of patients with severe headache/migraine.
- White matter hyperintensities and headache in United States military veterans with mild traumatic brain injuryby Kiersten I Mangold on 3 Dicembre 2024
CONCLUSIONS: Our findings suggest that neither migraine-like headache nor severity of headache is associated with increased prevalence of white matter hyperintensities in veterans with a history of mild traumatic brain injury.
- Histoire de la prise en charge de la douleur de l'enfantby Daniel Annequin on 3 Dicembre 2024
No abstract
- An Osteopathic Approach to Foot Drop: A Case Report of Posterior Fibular Headby Mikhail Volokitin on 2 Dicembre 2024
Chronic foot drop can present a diagnostic challenge, often leading to extensive medical evaluations without definitive resolution. We report a case of a 42-year-old female with an elusive cause of foot drop, a complex and engaging case that required extensive medical evaluations. The patient's complex medical history includes kidney infections, migraine headaches, and irritable bowel syndrome, treated with conventional medications and osteopathic manipulative techniques. The foot drop onset was...
- Patent Foramen Ovale (PFO): History, Diagnosis, and Managementby Aurel Maloku on 2 Dicembre 2024
Current guidelines recommend closing a patent foramen ovale (PFO) in patients who have experienced a cryptogenic or cardioembolic stroke, have a high-risk PFO, and are aged between 16 and 60 years (class A recommendation, level I evidence). In terms of efficacy, in the CLOSE and RESPECT trials, the number needed-to-treat (NNT) to prevent one stroke recurrence in a five-year term was between 20 and 44. Other trials, such as the REDUCE trial, presented much better data with a NNT of 28 at two...
- Food as migraine triggerby Hadda Margret Haraldsdottir on 2 Dicembre 2024
CONCLUSION: Food seems to be a common migraine trigger, and the main food-related triggers were similar to those reported in other studies. However, previous studies have not shown liquorice as a common food trigger for migraines, and smoked meat was found to be a more common trigger than seen in other studies.
- Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric populationby Michelle Sader on 3 Dicembre 2024
CONCLUSIONS: This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition.
- Gut Microbiota Regulates Food Intake in a Rodent Model of Intermittent Limited Access to Palatable Foodby Thomas Demangeat on 3 Dicembre 2024
OBJECTIVE: Binge-eating disorder is characterized by recurrent episodes of consumption of large amounts of food within a short period of time, without compensatory purging behaviors. This disease is a major public health issue and is associated with numerous comorbidities, encompassing anxiety and depression. The gut microbiota has been proposed to be an important player in the onset or maintenance of eating disorders. Here, we aim to better delineate the potential role of the gut microbiota in...
- Therapists' perspectives on the Maudsley model anorexia nervosa treatment for adolescents and young adults (MANTRa): A qualitative interview studyby Michael Zeiler on 3 Dicembre 2024
CONCLUSIONS: The findings suggest how the MANTRa content (e.g. inclusion of additional therapeutic tools), the therapists' training and the format (e.g. provision of a digital version) can be improved to reach maximum impact. Therapists' formulation letters may be an effective therapeutic tool not only for AN but also across the spectrum of psychiatric disorders in adolescents and young adults.
- Virtual Reality as an Innovative Tool for Eating Disorders Psychological Treatmentby Abdulnaser Fakhrou on 3 Dicembre 2024
CONCLUSION: This review highlights how VR, with its specific characteristics, serves as an excellent ally to enhance both assessment and treatment for EDs. Future research should focus on filling existing gaps and delving into aspects not yet explored. One potential development could involve creating guidelines for VR use in EDs.
- Adverse Neonatal Outcomes Among Children Born to Mothers Eating Disorders: A Register-Based Cohort Studyby Hannah Chatwin on 2 Dicembre 2024
CONCLUSIONS: Children born to mothers with EDs have an increased risk of some adverse neonatal outcomes, with more pronounced risks in recent than past EDs. These results underscore the need for improved prevention of maternal EDs and enhanced monitoring throughout pregnancy to mitigate adverse outcomes.
- Navigating (Dis)empowerment: Dialectical Tensions in the Enactment of Resilience of College Students with Eating Disordersby Meina Liu on 2 Dicembre 2024
Research has shown a dramatic increase of eating disorders (EDs) among young people during disruptive times. Understanding the role of communication in impeding or enacting resilience not only helps those with EDs develop better strategies for coping and changing their lives but can also inform effective interventions at familial, community, and system levels. Guided by the communication theory of resilience (CTR), our study explores how college students with EDs enacted resilience through...
- Übersichtsarbeiten / Review Articles. Achtsamkeit im Zusammenhang mit Suchtstörungen des Kindes- und Jugendalters: Überblick über den aktuellen Stand der Forschung / Mindfulness in the Context of Addiction Disorders in Childhood and Adolescence: Overview of the Current State of Researchby Nicolas Arnaud on 3 Dicembre 2024
Mindfulness in the Context of Addiction Disorders in Childhood and Adolescence: Overview of the Current State of Research Adolescents are at an increased risk of developing addictive disorders due to a variety of risk factors. Addictive behaviour is characterised by a limited ability to control one's own behaviour. The potential of improved self-regulation through mindfulness-based interventions is increasingly being investigated in connection with addictive behaviour. Whether a benefit also...
- A multicenter, single-group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention-deficit/hyperactivity disorder: Study protocolby Naoki Takamatsu on 3 Dicembre 2024
CONCLUSIONS: This study is essential for the development of CBT interventions in accordance with Japan's healthcare system that are tailored to the unique needs of its population.
- Association of Neuropsychiatric Inventory Questionnaire Score With Caregiver Relationship in Alzheimer's Disease Dementia and Mild Cognitive Impairmentby Yasuyuki Honjo on 3 Dicembre 2024
Behavioral and psychological symptoms of dementia (BPSD) can appear not only in Alzheimer's disease dementia (ADD) but in mild cognitive impairment (MCI). This study examined the association of BPSD with caregiver relationship, using the Neuropsychiatric Inventory Questionnaire (NPI-Q) score. The cognitive function of 419 new outpatients with ADD or MCI was evaluated using the Revised Hasegawa Dementia Scale (HDS-R) and the Mini-Mental State Examination (MMSE). Caregiver relationship was...
- Psychotherapy in Treating Female Sexual Dysfunctionby Erika L Kelley on 3 Dicembre 2024
This paper provides a summary of the biopsychosocial approach to the identification of female sexual dysfunction, with a particular focus on psychological, interpersonal, and sociocultural components. A summary of psychotherapeutic approaches to the management of female sexual dysfunction, for cases warranting a specialist referral, is provided. Approaches including sensate focus sex therapy, cognitive behavioral therapy, mindfulness-based approaches, and systematic desensitization are...
- Analysis of Influencing Factors Related to Health Literacy of Diabetic Patients: A Survey Based on DHLEISby Yalan Chen on 3 Dicembre 2024
Purpose: This study is aimed at investigating health literacy (HL) among diabetes mellitus (DM) patients using a comprehensive, scientific, feasible, and suitable HL assessment indicator system tailored for the diabetic population in mainland China and systematically analyzing the factors influencing HL in this population. Methods: The Delphi expert consultation method was employed to initially draft and refine the Diabetes Health Literacy Evaluation Indicator System (DHLEIS). The reliability...
- Epilepsy and psychiatric disorders (epi-psy)by Alexis Tarrada on 3 Dicembre 2024
EPILEPSY AND PSYCHIATRIC DISORDERS (EPI-PSY). Epilepsy is not only a brain pathology characterized by a lasting predisposition to generate seizures, it is also associated with cognitive, behavioral, psychological, and social disorders. The interaction between psychiatric pathologies and epilepsy is bidirectional and complex. This association is summarized in the neologism Epi-Psy. Psychiatric pathologies affect at least one third of epileptic patients and up to 80% in cases of drug-resistant...
- TMS in the Kingdom of Denmark: an overview of current clinical practiceby Pedro Cabral Barata on 30 Novembre 2024
CONCLUSIONS: rTMS is unequally available in the public healthcare of the Kingdom of Denmark. Existing strategies for solving inequalities could address such issues. Unipolar depression was the only psychiatric disorder treated with rTMS in 2023. rTMS practice in the Danish Realm considers the use of evidence-based protocols and is consistent with recommendations from international expert guidelines.
- The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological studyby Fioravante Capone on 29 Novembre 2024
CONCLUSIONS: Our study demonstrated that cholinergic circuits explored by SAI are different from circuits engaged by taVNS.
- Functional motor network abnormalities associated with levodopa-induced dyskinesia in Parkinson's disease: A systematic reviewby Birgitte Liang Chen Thomsen on 22 Novembre 2024
Parkinson's disease (PD) can be effectively treated with levodopa and dopamine agonists but leads to levodopa-induced dyskinesia (LID) in most patients in the long run. Various functional brain mapping techniques are used to explore alterations in motor networks associated with LID. This pre-registered review (PROSPERO: CRD42022320830) summarizes the motor network abnormalities reported in functional brain mapping studies of patients with LID. We included studies using functional MRI, EEG, PET,...
- Stakeholder perspectives on non-invasive brain stimulationby Moritz Julian Maier on 20 Novembre 2024
Non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) have made great progress in recent years and offer boundless potential for the neuroscientific research and treatment of disorders. However, the possible use of NIBS devices for neuro-doping and neuroenhancement in healthy individuals and the military are poorly regulated. The great potentials and diverse applications can have an impact on the future...
- A multisite observational real-world study on the effectiveness of repetitive transcranial magnetic stimulation therapy for patients with treatment-resistant depression in Japanby Yuki Matsuda on 16 Novembre 2024
The objective of this study was to reveal the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for Japanese patients with treatment-resistant depression (TRD) in clinical practice, based on real-world data from a nationwide multicenter observational study in Japan. Clinical data of patients with TRD treated with rTMS (NeuroStar TMS treatment system) under public insurance coverage were retrospectively collected from 21 institutes nationwide between June 2019 and December...
- Microorganisms isolated from thermoplastic masks and storage racks in head and neck cancer patients with radiation dermatitisby Özlem Koca on 16 Novembre 2024
Healthcare-associated infections (HAIs) remain a critical public health issue, as they contribute to prolonged treatment duration, increased healthcare costs, and heightened risks of morbidity and mortality. In head and neck cancer patients undergoing radiotherapy, thermoplastic masks (TMs), which come into direct contact with the skin, represent a potential vector for infection. Additionally, the storage racks where these masks are kept may also facilitate microorganism transmission. Our study...
